Clinical pharmacology of antihypertensive agents. Future view of antihypertensive agents. New antihypertensive agents.

Assessing Clinical Efficacy of Available Antihypertensive Agents

Drug interactions of antihypertensive agents

Adverse drug-drug interactions may occur when a major therapeutic mechanism of one drug class (such as bradycardia with a beta blocker) is excessively exaggerated by the addition of another heart-rate slowing antihypertensive, such as verapamil. The most important interactions at the molecular level are those of the hepatic enzyme, cytochrome (CYP) 3A4. A classic example is the inhibitory effec...

Pulse pressure and antihypertensive agents.

Pulse Pressure and Antihypertensive Agents To the Editor: In their subanalysis of the LIFE study,1 the authors conclude that they “show superior protection against stroke in patients treated with losartan when compared with atenolol . . . This difference may be related to specific effects of angiotensin type 1 receptor antagonism . . . beyond blood BP reduction.” The authors do not consider the...

Contrasting metabolic effects of antihypertensive agents.

Hypertension often coexists with hyperlipidemia, insulin resistance, and glucose intolerance, a comorbidity known as metabolic syndrome X. Different antihypertensives have mixed effects on these associated abnormalities. We compared three antihypertensives in the spontaneously hypertensive obese rat model of syndrome X. Moxonidine (4 mg/kg), an imidazoline and alpha2-adrenergic agonist, alpha-m...

Effect of antihypertensive agents - captopril and nifedipine - on the functional properties of rat heart mitochondria

Objective(s): Investigation of acute effect on cellular bioenergetics provides the opportunity to characterize the possible adverse effects of drugs more comprehensively. This study aimed to investigate the changes in biochemical and biophysical properties of heart mitochondria induced by captopril and nifedipine antihypertensive treatment. Materials and Methods: Male, 12-week-old Wistar rats i...